Tartaric Acid
Selleck Chemical LLC ENMD-2076 S1181-1g
ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1 86 nM 25-fold selective for Aurora A than over Aurora B and less potent to RET SRC NTRK1/TRKA CSF1R/FMS VEGFR2/KDR FGFR and PDGFR ENMD-2076 inhibits the growth of a wide range of human solid tumor and hematopoietic cancer cell lines with IC50 from 0 025 to 0 7 M which induces apoptosis and G2/M phase arrest Phase 2
Sigma Aldrich Fine Chemicals Biosciences Sodium tartrate dihydrate United States Pharmacopeia (USP) Reference Standard | 6106-24-7 | MFCD00150035 | 4X500MG
Sodium tartrate dihydrate United States Pharmacopeia (USP) Reference Standard | Mol Wt: 230.08 | 6106-24-7 | MFCD00150035 | 4X500MG
Medchemexpress LLC 6-(4-methylpiperazin-1-yl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(E)-2-phenylethenyl]pyrimidin-4-amine | 934353-76-1 | MFCD16619371 | 100.0% | 375.47 | 10 MG
ENMD-2076 is a multi-targeted kinase inhibitor that selectively binds to and inhibits tyrosine and Aurora kinases. This action can lead to the inhibition of cell division and proliferation, and may induce apoptosis in tumor cells. It also exhibits antiangiogenic activity, making it suitable for various research applications.
- Inhibits multiple kinases including Aurora A, Flt3, KDR/VEGFR2, and FGFR1.
- Demonstrates antiproliferative activity against human cell lines.
- Induces G2-M-phase arrest and apoptosis.
- Inhibits Flt3 ligand (FL)-induced Flt3 autophosphorylation.
- Inhibits VEGFR2/KDR autophosphorylation.
- Shows dose-dependent inhibition of tumor growth in vivo.
Medchemexpress LLC Prednisolone disodium phosphate | 125-02-0 | 99.5% | 1 ML
Prednisolone disodium phosphate is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. It can be rapidly and completely hydrolyzed to Prednisolone in the plasma.
- Synthetic glucocorticoid
- Exhibits anti-inflammatory properties
- Possesses immunomodulating properties
- Rapidly hydrolyzed to Prednisolone in plasma
- Soluble in water (50 mg/mL) and PBS (100 mg/mL)
- Available in solid and solution forms
Medchemexpress LLC ENMD-2076 | 934353-76-1 | 99.99% | 375.47 | 100 MG
ENMD-2076 is a multi-targeted kinase inhibitor with high selectivity towards Aurora A versus Aurora B. It inhibits HUVEC growth and shows antiproliferative effects on human leukemia cell lines. This compound induces G2-M-phase arrest and apoptosis in U937 cells and inhibits Flt3 and Kit autophosphorylation. In vivo, ENMD-2076 demonstrates dose-dependent inhibition of tumor growth and is well tolerated in animal studies.
- Multi-targeted kinase inhibitor.
- Inhibits HUVEC growth.
- Shows antiproliferative effects on leukemia cell lines.
- Induces G2-M-phase arrest and apoptosis.
- Inhibits Flt3 ligand (FL)-induced Flt3 autophosphorylation.
- Inhibits stem cell factor (SCF)-induced Kit autophosphorylation.
- Inhibits VEGFR2/KDR autophosphorylation.
- Results in dose-dependent inhibition of tumor growth in vivo.
Medchemexpress LLC ENMD-2076 Tartrate | 1453868-32-0 | 99.66% | 525.56 | 50 MG
ENMD-2076 Tartrate is a multi-targeted kinase inhibitor primarily targeting Aurora A, Flt3, and VEGFR2. It is intended for research use only and not for patient applications. This compound is known for its inhibitory effects on various kinases, contributing to its potential in anti-proliferative and anti-angiogenic research.
- Exhibits potent inhibition of Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, and PDGFRα.
- Induces G2-M-phase arrest and apoptosis in U937 cells.
- Inhibits Flt3 and Kit autophosphorylation.
- Shows dose-dependent inhibition of tumor growth in vivo.
Medchemexpress LLC Fostamatinib (disodium hexahydrate) | 914295-16-2 | 99.5% | 25 MG
Fostamatinib (disodium hexahydrate) is a laboratory chemical provided as a solid with a purity of 99.5%. It requires sealed storage at 4°C away from moisture. When in solvent, it can be stored at -80°C for 6 months or -20°C for 1 month.
- Stable under recommended storage conditions
- Requires sealed storage to protect from moisture
- Recommended storage at 4°C
- For solutions, store at -80°C (up to 6 months) or -20°C (up to 1 month)
Medchemexpress LLC Tartaric acid (sodium hydrate) | 6131-98-2 | MFCD00150038 | 190.08 g/mol | C4H7NaO7 | 500 G
Tartaric acid sodium hydrate is the sodium salt hydrate of L-(+)-tartaric acid supplied as a white to off-white crystalline solid for laboratory and food-related applications. It is used as an endogenous metabolite reagent and described as a food additive; product documentation including SDS and COA is provided by the supplier.
Medchemexpress LLC ENMD-2076 Tartrate | 1453868-32-0 | 99.7% | 525.56 | 10 MG
ENMD-2076 Tartrate is a multi-targeted kinase inhibitor with IC50s of 1.86, 14, 58.2, 15.9, 92.7, 70.8, 56.4 nM for Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα, respectively. It is for research use only and not sold to patients.
- Acts as a multi-targeted kinase inhibitor
- Inhibits Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, and PDGFRα
- Shows selective inhibition of Aurora A over Aurora B
- Inhibits human umbilical vein endothelial cell (HUVEC) growth
- Blocks cellular Flt3 ligand (FL)-induced Flt3 autophosphorylation
- Prevents stem cell factor (SCF)-induced Kit autophosphorylation
- Inhibits VEGFR2/KDR autophosphorylation
- Demonstrates dose-dependent inhibition of tumor growth or tumor regression in vivo
- Exhibits good tolerance in daily doses during in vivo studies
Medchemexpress LLC Prednisolone (disodium phosphate) | 125-02-0 | MFCD00083682 | 99.0% | 484.39 | C21H27Na2O8P | 10 MG
Prednisolone disodium phosphate (Standard) is an analytical reference standard of the corticosteroid prednisolone, supplied for research and analytical applications. It is provided as a solid and in ready-to-use solution formats for assay development and method validation.
- Analytical reference standard for prednisolone assays.
- Measured purity 98.98% (HPLC) with assay data provided.
- Molecular formula C21H27Na2O8P, molecular weight 484.39 g/mol.
- Available in small to bulk pack sizes, including 10 mg solid and 10 mM solution formats.
- Supplied with datasheet, certificate of analysis, and SDS for traceability.
- Intended for research use only; not for human or veterinary use.